Named after the English nobleman Lord Hugh Seymour, North Seymour was formed by a series of uplifts of submarine lava along with Baltra (also called South Seymour) and the northeastern part of Santa Cruz, resulting in flat plateaus. In the early 1930s, members of the Hancock Expeditions moved approximately 70 land iguanas from Baltra Island to North Seymour in order to provide better conditions for their survival, as introduced goats were destroying the habitat on Baltra and contributing to their declining population. Land iguanas are not native to North Seymour Island.
North Seymour is now home to nearly 2,500 land iguanas, according to a 2014 census by the Galapagos National Park (GNP). This island also hosts large populations of blue-footed boobies, swallow-tailed gulls, common noddies, and frigatebirds.